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Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Advances in Allogeneic Hematopoietic Stem Cell Transplantation PDF Author: Richard K. Burt
Publisher: Springer Science & Business Media
ISBN: 9780792377146
Category : Medical
Languages : en
Pages : 440
Book Description
The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Advances in Allogeneic Hematopoietic Stem Cell Transplantation PDF Author: Richard K. Burt
Publisher: Springer Science & Business Media
ISBN: 9780792377146
Category : Medical
Languages : en
Pages : 440
Book Description
The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

Advances and Challenges of Allogeneic Stem Cell Transplantation

Advances and Challenges of Allogeneic Stem Cell Transplantation PDF Author: Michele Malagola
Publisher: Frontiers Media SA
ISBN: 2889746925
Category : Medical
Languages : en
Pages : 193
Book Description


Advances in Hematopoietic Stem Cell Research

Advances in Hematopoietic Stem Cell Research PDF Author: Rosana Pelayo
Publisher: BoD – Books on Demand
ISBN: 9533079304
Category : Science
Languages : en
Pages : 480
Book Description
This book provides a comprehensive overview in our understanding of the biology and therapeutic potential of hematopoietic stem cells, and is aimed at those engaged in stem cell research: undergraduate and postgraduate science students, investigators and clinicians. Starting from fundamental principles in hematopoiesis, Advances in Hematopoietic Stem Cell Research assemble a wealth of information relevant to central mechanisms that may regulate differentiation, and expansion of hematopoietic stem cells in normal conditions and during disease.

Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Advances in Allogeneic Hematopoietic Stem Cell Transplantation PDF Author: Richard K. Burt
Publisher: Springer
ISBN: 1461549876
Category : Medical
Languages : en
Pages : 414
Book Description
The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

Bone Marrow Cells—Advances in Research and Application: 2013 Edition

Bone Marrow Cells—Advances in Research and Application: 2013 Edition PDF Author:
Publisher: ScholarlyEditions
ISBN: 1481673629
Category : Medical
Languages : en
Pages : 290
Book Description
Bone Marrow Cells—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Monocytes. The editors have built Bone Marrow Cells—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Monocytes in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Marrow Cells—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Integration of Graphics and OSI Standards

Integration of Graphics and OSI Standards PDF Author: Robert A. Day
Publisher: Springer Verlag
ISBN: 9780387570150
Category : Computers
Languages : en
Pages : 157
Book Description
ESPRIT, the European Specific Research and Technological Development Programme in the field of Information Technologies, was set up in 1984 as a cooperative research programme involving European IT companies, large and small, and academic institutions. Managed by DG III of the European Commission, its aim is to contribute to the development of a competitive industrial base in an area of crucial importance for the entire European economy. The current phase of ESPRIT (the third) comprises five technological areas (Microelectronics, Design and Engineering Technology for Software-Intensive Systems, High-Performance Computing and its Applications, Advanced Business and Home Systems plus Peripherals. Computer-Integrated Manufacturing and Engineering), Basic Research and the Open Microprocessor Systems Initiative, which draws on all other areas of the programme. The series Research Reports ESPRIT is helping to disseminate the many results - products and services, tools and methods, and international standards - arising from the hundreds of projects, involving thousands of researchers, that have already been launched.

Hematopoietic Stem Cell Transplantation Research Advances

Hematopoietic Stem Cell Transplantation Research Advances PDF Author: Karl B. Neumann
Publisher: Nova Publishers
ISBN: 9781604560428
Category : Medical
Languages : en
Pages : 262
Book Description
Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (that is, bone marrow transplantation) or blood. Stem cell transplantation is a medical procedure in the fields of haematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer. Stem cell transplantation was pioneered using bone-marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognised with a Nobel Prize in Physiology and Medicine. Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells. His work also reduced the likelihood of developing a life-threatening complication called Graft-versus-host disease. With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoeitic stem cell transplantation procedures are now performed using stem cells collected from the peripheral blood, rather than from the bone marrow. Collecting stem cells provides a bigger graft, and does not require that the donor be subjected to general anaesthesia to collect the graft. Hematopoeitic stem cell transplantation remains a risky procedure with many possible complications; it has always been reserved for patients with life-threatening diseases. This book presents recent leading research in the field.

Advances in Hematopoietic System Research and Application: 2013 Edition

Advances in Hematopoietic System Research and Application: 2013 Edition PDF Author:
Publisher: ScholarlyEditions
ISBN: 148167062X
Category : Medical
Languages : en
Pages : 272
Book Description
Advances in Hematopoietic System Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Advances in Hematopoietic System Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Hematopoietic System Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation PDF Author: Anthony D. Ho
Publisher: CRC Press
ISBN: 9780824702731
Category : Medical
Languages : en
Pages : 624
Book Description
This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life. Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation summarizes current understanding and development of clinical allogeneic HSC transplantation discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors details detection of bone marrow contamination by tumor cells and removal procedures focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors explores the effects of growth factor administration and leukapheresis on PB stem cell donors shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells employs automated fluorescence image cytometry to study early HSC behavior following seeding Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study, Hematopoietic Stem Cell Transplantation is a blue-chip reference for hematologists, hematopathologists, oncologists, cytotherapists, transplantation immunologists, and molecular biologists.

New Advances in Stem Cell Transplantation

New Advances in Stem Cell Transplantation PDF Author: Taner Demirer
Publisher: BoD – Books on Demand
ISBN: 9535100130
Category : Science
Languages : en
Pages : 598
Book Description
This book documents the increased number of stem cell-related research, clinical applications, and views for the future. The book covers a wide range of issues in cell-based therapy and regenerative medicine, and includes clinical and preclinical chapters from the respected authors involved with stem cell studies and research from around the world. It complements and extends the basics of stem cell physiology, hematopoietic stem cells, issues related to clinical problems, tissue typing, cryopreservation, dendritic cells, mesenchymal cells, neuroscience, endovascular cells and other tissues. In addition, tissue engineering that employs novel methods with stem cells is explored. Clearly, the continued use of biomedical engineering will depend heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments.