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Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Advances in Allogeneic Hematopoietic Stem Cell Transplantation PDF Author: Richard K. Burt
Publisher: Springer Science & Business Media
ISBN: 9780792377146
Category : Medical
Languages : en
Pages : 440
Book Description
The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Advances in Allogeneic Hematopoietic Stem Cell Transplantation PDF Author: Richard K. Burt
Publisher: Springer Science & Business Media
ISBN: 9780792377146
Category : Medical
Languages : en
Pages : 440
Book Description
The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

Advances and Challenges of Allogeneic Stem Cell Transplantation

Advances and Challenges of Allogeneic Stem Cell Transplantation PDF Author: Michele Malagola
Publisher: Frontiers Media SA
ISBN: 2889746925
Category : Medical
Languages : en
Pages : 193
Book Description


Allogeneic Stem Cell Transplantation

Allogeneic Stem Cell Transplantation PDF Author: Mary J. Laughlin
Publisher: Springer Science & Business Media
ISBN:
Category : Medical
Languages : en
Pages : 474
Book Description
Leading authorities provide a valuable account of the clinical and labratory issue related to allogeneic stem cell transplantation. Key chapters feature such topics as the selection of optimal inrelated allogeneic grafts for patients with hematologic malignancies; issues related to stem cell mobilization in normal donors; allogeneic peripheral blood cell vs marrow-derived transplantation; umbilical cord blood as a new stem cell source; kinetics of immune reconstitution post allogeneic transplantation; the role of allogeneic transplantation in breast cancer, and; the application of mini-conditioning in allogeneic grafting. The book will serve as a guide in development of innovative clinical and labratory inquiry in the field of allogeneic transplantation for all clinicians and labratory investigators focused on hematopoetic stem cells and immune biology research.

Thomas' Hematopoietic Cell Transplantation, 2 Volume Set

Thomas' Hematopoietic Cell Transplantation, 2 Volume Set PDF Author: Stephen J. Forman
Publisher: John Wiley & Sons
ISBN: 1118416007
Category : Medical
Languages : en
Pages : 1775
Book Description
Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation PDF Author: Gerard Socie
Publisher: Academic Press
ISBN: 9780128126301
Category :
Languages : en
Pages : 540
Book Description
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation, Second Edition: Models in Discovery and Translation provides clinical and scientific researchers with a deep understanding of the current research in this field and its implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance prospects for the future. New sections focus on microbiome, metabolism, micro-RNA and mRNA regulatory mechanisms and pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies and immune system engagers for GVHD and graft-vs-tumor (GVT), and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models Categorizes published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation PDF Author: Michael R. Bishop
Publisher: Springer Science & Business Media
ISBN: 9780387785806
Category : Medical
Languages : en
Pages : 589
Book Description
The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.

Non-Myeloablative Allogeneic Transplantation

Non-Myeloablative Allogeneic Transplantation PDF Author: Asad Bashey
Publisher: Springer Science & Business Media
ISBN: 146150919X
Category : Medical
Languages : en
Pages : 216
Book Description
Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Thomas' Hematopoietic Cell Transplantation

Thomas' Hematopoietic Cell Transplantation PDF Author: Stephen J. Forman
Publisher: John Wiley & Sons
ISBN: 1118416120
Category : Medical
Languages : en
Pages : 1416
Book Description
Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

Manual of Stem Cell and Bone Marrow Transplantation

Manual of Stem Cell and Bone Marrow Transplantation PDF Author: Joseph H. Antin
Publisher: Cambridge University Press
ISBN: 0521699754
Category : Medical
Languages : en
Pages : 193
Book Description
This multidisciplinary pocket manual covers all aspects of the transplantation process, from stem cell processing to patient counseling.

Pediatric Hematopoietic Stem Cell Transplantation for Pharmacists

Pediatric Hematopoietic Stem Cell Transplantation for Pharmacists PDF Author: Carolina Witchmichen Penteado Schmidt
Publisher: Springer Nature
ISBN: 3030434915
Category : Medical
Languages : en
Pages : 123
Book Description
This unique book is the first on pediatric hematopoietic stem cell transplantation that is especially intended for pharmacists – in recognition of the fact that Pediatric Oncology Pharmacy is an area where more and more specific knowledge is required in daily practice, yet pharmacists who work in pediatric stem cell transplantation do not have a book addressing their specific needs. This pioneering book will likely become the new gold standard for practice, addressing subjects such as stem cells and their differentiation mechanisms; aspects of embryonic and non-embryonic stem cells; stem cell transplantation in pediatrics; stem cell sources and related technical choices; stem cell donors; scheduling transplantations; diseases and chemotherapy protocols that require stem cell transplantation; stem cell homing; engraftment and repopulation of stem cells in bone marrow; autologous stem cell transplantation in pediatrics; allogeneic stem cell transplantation in pediatrics; and indications for autologous and allogeneic pediatric stem cell transplantation. Further, it discusses pediatric graft-versus-host disease and the pharmacist; antibacterial and antifungal prophylaxis; detailed chemotherapy, conditioning and trials for pediatric stem cell transplantation; conditioning granulocyte colony-stimulating factor (G-CSF) in pediatric stem cell transplantation; analyzing prescriptions and programming a pediatric stem cell transplantation; handling chemotherapy and adjuvant drugs for pediatric stem cell transplantation; stem cell transplantation in children up to 1 year old; and clinical pharmacy in pediatric stem cell transplantation. An easy-to-read yet comprehensive guide covering a wide range of topics essential to daily practice, the book offers an invaluable asset for pediatric hemato/ oncology pharmacists, hematologist pharmacists, clinical pharmacists, pediatric pharmacists, pharmaceutical residents and researchers alike.