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Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation PDF Author: Gerard Socie
Publisher: Academic Press
ISBN: 9780128126301
Category :
Languages : en
Pages : 540
Book Description
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation, Second Edition: Models in Discovery and Translation provides clinical and scientific researchers with a deep understanding of the current research in this field and its implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance prospects for the future. New sections focus on microbiome, metabolism, micro-RNA and mRNA regulatory mechanisms and pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies and immune system engagers for GVHD and graft-vs-tumor (GVT), and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models Categorizes published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation PDF Author: Gerard Socie
Publisher: Academic Press
ISBN: 9780128126301
Category :
Languages : en
Pages : 540
Book Description
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation, Second Edition: Models in Discovery and Translation provides clinical and scientific researchers with a deep understanding of the current research in this field and its implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance prospects for the future. New sections focus on microbiome, metabolism, micro-RNA and mRNA regulatory mechanisms and pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies and immune system engagers for GVHD and graft-vs-tumor (GVT), and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models Categorizes published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

Thomas' Hematopoietic Cell Transplantation

Thomas' Hematopoietic Cell Transplantation PDF Author: Stephen J. Forman
Publisher: John Wiley & Sons
ISBN: 1118416120
Category : Medical
Languages : en
Pages : 1416
Book Description
Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

Thomas' Hematopoietic Cell Transplantation, 2 Volume Set

Thomas' Hematopoietic Cell Transplantation, 2 Volume Set PDF Author: Stephen J. Forman
Publisher: John Wiley & Sons
ISBN: 1118416007
Category : Medical
Languages : en
Pages : 1775
Book Description
Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

Cells of the Immune System

Cells of the Immune System PDF Author: Ota Fuchs
Publisher: BoD – Books on Demand
ISBN: 1789855837
Category : Medical
Languages : en
Pages : 248
Book Description
The cells of the immune system are lymphocytes (T-cells, B-cells and NK (natural killer) cells), neutrophils, eosinophils, and monocytes/macrophages. This book is an overview of some types of these cells and their role in recognizing and/or reacting against foreign material. The immune system is characterized by collaboration between cells and proteins. The development of all cells of the immune system begins in the bone marrow with a hematopoietic stem cell. Two chapters deal with neutrophils, three chapters with T-cells, four chapters with eosinophils, and other chapters review the immunomodulation of macrophages, the role of transcription factor KLF4 in regulating plasticity of myeloid-derived suppressor cells, immune reconstitution after allogeneic hematopoietic stem cell transplantation, and role of sorption detoxification in the therapy of acute radiation sickness.

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation PDF Author: Gerard Socie
Publisher: Academic Press
ISBN: 0128134399
Category : Science
Languages : en
Pages : 430
Book Description
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

Clinical Bone Marrow and Blood Stem Cell Transplantation

Clinical Bone Marrow and Blood Stem Cell Transplantation PDF Author: Kerry Atkinson
Publisher: Cambridge University Press
ISBN: 9780521829120
Category : Medical
Languages : en
Pages : 2210
Book Description
A definitive reference in its third edition on the practice of hematopoietic stem cell transplantation.

Cell Therapy

Cell Therapy PDF Author: Y. Ikeda
Publisher: Springer Science & Business Media
ISBN: 4431685065
Category : Science
Languages : en
Pages : 240
Book Description
Modern cell biology has brought improvements in therapy for advanced malignant diseases through immunomodulation, hematopoietic stem cell transplantation, and other advanced techniques. Collected here are selected papers from the Fifth International Symposium of Keio University for Life Sciences and Medicine on Cell Therapy. All chapters include innovative basic research for clinical application: immunotherapy, cancer vaccination, molecular biology of hematopoietic stem cells, stem cell processing, and gene therapy. The book is divided into three parts: Immunotherapy for malignant diseases; Hematopoietic stem cell biology and clinical application; and International collaboration in hematopoietic stem cell transplantation. Included in the third part is information on bone marrow registries from around the world. The book thus presents up-to-date information on biological and clinical aspects of treatment, with insight into the future of cell therapy.

Allogeneic Stem Cell Transplantation

Allogeneic Stem Cell Transplantation PDF Author: Mary J. Laughlin
Publisher: Springer Science & Business Media
ISBN:
Category : Medical
Languages : en
Pages : 474
Book Description
Leading authorities provide a valuable account of the clinical and labratory issue related to allogeneic stem cell transplantation. Key chapters feature such topics as the selection of optimal inrelated allogeneic grafts for patients with hematologic malignancies; issues related to stem cell mobilization in normal donors; allogeneic peripheral blood cell vs marrow-derived transplantation; umbilical cord blood as a new stem cell source; kinetics of immune reconstitution post allogeneic transplantation; the role of allogeneic transplantation in breast cancer, and; the application of mini-conditioning in allogeneic grafting. The book will serve as a guide in development of innovative clinical and labratory inquiry in the field of allogeneic transplantation for all clinicians and labratory investigators focused on hematopoetic stem cells and immune biology research.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation PDF Author: Robert J. Soiffer
Publisher: Springer Science & Business Media
ISBN: 9781597454384
Category : Medical
Languages : en
Pages : 736
Book Description
Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease. Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair. The updated chapters introduce the biologic underpinnings of hematopoietic cell transplantation, basic stem cell biology, immunobiology, and histocompatibility, with emphasis on indications and results of transplantation for specific diseases. Written by experts in the field, Stem Cell Transplantation for Hematologic Disorders, Second Edition provides seasoned professionals with a complete understanding of the current state of transplantation biology as well as a clear vision into the future.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation PDF Author: Michael R. Bishop
Publisher: Springer Science & Business Media
ISBN: 9780387785806
Category : Medical
Languages : en
Pages : 589
Book Description
The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.