Liposome-Based Drug Delivery Systems

Liposome-Based Drug Delivery Systems PDF Author: Wan-Liang Lu
Publisher: Springer
ISBN: 9783662493182
Category : Technology & Engineering
Languages : en
Pages : 489
Book Description
This volume describes the protocols for fabrication of liposomal drug delivery system, and consists of two parts. The first part emphasizes the basic protocols and concepts for fabrication of drug-loaded liposomes. For new investigators, laying the groundwork is the first step. This part focuses on the fabrication details in liposomes formulations, which are the so-called small tricks while usually not disclosed in mostly published research articles. However, these processing details are crucial for the preparation of liposomes. And the second part focuses on the strategies in modified and/or functionalized liposomes to adapt to pathophysiological environment, as well as their application in treating diseases. As new analytical and synthetic technologies become available, and improved understanding of pathophysiology, various functionalized drug liposomes are developing to fit the requirements of different therapeutic purposes, exhibiting a broad range of applications. Accordingly, the objectives of this part are aimed at deeply unearthing the formulation of drug-loaded liposomes, describing the detailed operation of liposomal formulation, and further demonstrating their potential applications. Therefore, this volume shows the features of experimental report or protocol for proving a guide to scientists, research students, and young investigators in pharmaceutical enterprises.

Liposomes

Liposomes PDF Author: Angel Catala
Publisher: BoD – Books on Demand
ISBN: 9535135791
Category : Science
Languages : en
Pages : 327
Book Description
Liposomes have received increased attention in recent years. Nevertheless, liposomes, due to their various forms and applications, require further investigation. These structures can deliver both hydrophilic and hydrophobic drugs. Preparation of liposomes results in different properties for these systems. In addition, there are many factors and difficulties that affect the development of liposome drug delivery structure. The purpose of this book is to concentrate on recent developments on liposomes. The articles collected in this book are contributions by invited researchers with a long-standing experience in different research areas. We hope that the material presented here is understandable to a broad audience, not only scientists but also people with general background in many different biological sciences. This volume offers you up-to-date, expert reviews of the fast-moving field of liposomes.

A Novel Approach for Topical Drug Delivery: Liposome Based Gel

A Novel Approach for Topical Drug Delivery: Liposome Based Gel PDF Author: Hardik K. Patel
Publisher:
ISBN: 9783659241345
Category :
Languages : en
Pages : 0
Book Description


Engineering Synthetic and Natural Vesicular System for Tumor-targeted Drug Delivery

Engineering Synthetic and Natural Vesicular System for Tumor-targeted Drug Delivery PDF Author: Sagar Rayamajhi
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Nanomedicine provides exciting opportunities to solve modern-world medical problems from disease diagnosis to therapy. From the first approved nanomedicine in 1995 against cancer, Doxil®, to the recent sensation, lipid nanoparticle-based mRNA vaccine against COVID-19, nanomedicine has come a long way to the state of becoming a platform medical technology. Toward this endeavor, this dissertation is focused on lipid-based vesicles systems, synthetic liposomes, and cell-secreted extracellular vesicles (EVs), where we have explored and optimized efficient engineering techniques to achieve tumor-targeted drug delivery and diagnostic capacity. Liposomes are synthetic vesicles with an aqueous core and phospholipid bilayer and EVs are natural vesicles secreted by cells with protein-lipid bilayer and aqueous core carrying cellular information in terms of proteins and nucleic acid (mRNA, miRNA, DNA). These complementary properties when paired make them highly efficient delivery vehicles in a biological environment, an overarching goal of this dissertation. The main objective of this dissertation is to overcome two major challenges in nanoparticulate drug delivery system: 1) how to overcome endosome degradation of nanoparticles and maximize intracellular bioavailability and 2) how to overcome biological barriers for efficient delivery- rapid immune clearance, circulation stability, epithelial barriers, microenvironment barriers, cellular, and intracellular barriers. Toward this aim, we engineered a pH-sensitive liposome with pH-responsive 3[beta]-[N-(N',N'-dimethylaminoethane)-carbamoyl] (DC) moiety to avoid endosomal degradation. pH-sensitive liposome showed pH-responsive cationic properties which elevated the fusogenic characteristic of liposome at the acidic environment in the endosomes and facilitate endosomal escape via membrane fusion (Chapter 3). Although the in-vitro results were promising, the challenge to overcome the biological barrier remains. To overcome this problem, a natural messenger of the cellular system, which has been optimized with years of evolution, EVs, was used. We optimized a simple, efficient, and reproducible EVs isolation method by combining centrifugation, ultrafiltration, and size exclusion-based chromatography. Synthetic liposomes were used to engineer an EVs-based hybrid system that contributed to increasing overall yield, stability, and added functionality (Chapter 4). EVs derived from mouse macrophage J774A.1 showed preferential interaction toward cancer cells, both in vitro and in vivo mouse models showing promises for tumor-targeted drug delivery. Further, a gadolinium incorporated liposome was synthesized and hybridized with EVs to engineer a hybrid system with diagnostic capacity, which showed contrast-enhanced diagnostic characteristics as confirmed by clinical magnetic resonance imaging (Chapter 5). Finally, EVs were optimized for their reproducibility of physicochemical and functional properties. Rigorous EVs isolation technique and characterization confirmed the EVs production is significantly higher in cancer cells compared to non-cancer (Chapter 6). The nanosystems engineered in this study were successful to overcome endosomal degradation via escape, have longer retention time, good biocompatibility, efficient drug loading capacity, and tumor targeting characteristic, all of which are excellent properties for drug delivery systems. With this proof of concept and design consideration, this dissertation adds an important understanding of the vesicles-based system for tumor-targeted drug delivery. We envision that future works on the molecular mechanism behind the achieved biomimicry and tumor targeting potential can lead toward the translation of a vesicle-based system for tumor-targeted drug delivery.

Liposome as a Drug Delivery Vehicle

Liposome as a Drug Delivery Vehicle PDF Author: Suryakanta Swain
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659354526
Category :
Languages : en
Pages : 144
Book Description
Liposomes are found to be having passively targeted drug carrier to tumor cells because of its enhanced permeability and retention effect. Liposomes remain at the front of the drug delivery systems owing to its non-toxic, bio-degradable and non-immunogenic nature. It has been explored as carrier for delivery of drug molecules such as protein and peptides, genes, vaccines, genosomes, lipopolyplex, fusogenic liposomes and virsomes, etc. Stealth liposomes utilized for targeting hydrophilic anticancer drugs such as doxorubicin, mitoxantrone, etc. Still there is quest in developing drug delivery and drug targeting system utilizing liposomal formulations in the thrust area of cancer chemotherapy, antiviral, and such other biotechnological products.

Liposomal Drug Delivery

Liposomal Drug Delivery PDF Author: Devasrita U. Samal
Publisher: LAP Lambert Academic Publishing
ISBN: 9783847370703
Category :
Languages : en
Pages : 84
Book Description
Conventional drug delivery system were used for long time.Drug was usually administered in forms such as tablet, capsule, emulsion, suspension etc but administering drug using these conventional dosage form encountered a number of problems.The problems were mainly regarding poor distribution, stability, site delivery etc. most of these problems were solved by using Novel drug delivery system(NDDS). Liposome is one amongst those drug delivery system.With the help of liposomes it was possible to deliver the drug in a controlled manner. Drugs included in the liposomes directly reached to the site of action. With the help of liposomes it was possible to protect the physical and chemical degration. Hydrophillic as well as lipophillic drug could be administered with the help of liposome formulation. Liposomes are long circulating forms and thus it is possible to administer the drug with a sustained release profile. In liposomes as very few excipients, there is no interaction between the drug and polymer. Liposomes are least toxic. Thus because of these many advantages, it is considered as one of the best NDDS. But it also has a number of limitations.

Medical Applications of Liposomes

Medical Applications of Liposomes PDF Author: D.D. Lasic
Publisher: Elsevier
ISBN: 0080536085
Category : Science
Languages : en
Pages : 779
Book Description
The development of liposomes as a drug delivery system has fluctuated since its introduction in the late 1960's by A.D. Bangham. While academic research of liposomes as a model membrane system has always flourished, as the exponential growth of papers can testify, the application of these findings to medically useful products has gone through several crises. Following the original optimism in the 70's and early 80's, a period of severe skepticism ensued at the end of the 80's and beginning of the 90's, culminating in a moderate but real optimism in the mid 90's, as a result of a successful launch of the first products in the US and Europe. In this collection of papers, the editors have gathered the most promising ideas, approaches, applications and commercial developments, thereby presenting an up-to-date compilation of the present status of the field. This includes such broad areas as anti-cancer chemotherapy immune stimulation and infectious diseases. Currently, the major areas of progress are in delivery of anti-fungal agents by conventional liposomes or lipid-based carriers and systemic anticancer therapy using long-circulating liposomes. The future applications as characterized by the direction of present day research is in specific targeting and delivery of informational molecules such as DNA plasmids (genes), antisense oligonucleotides or ribozymes. Other future developments may be in topical delivery, vaccination and in diagnostics. Features of this book: • Contributions from almost all the leading labs in the field • Up-to-date, critical reviews bridged by editors' introductions • Organized into a logical framework.

Liposomes, Lipid Bilayers and Model Membranes

Liposomes, Lipid Bilayers and Model Membranes PDF Author: Georg Pabst
Publisher: CRC Press
ISBN: 1466507098
Category : Medical
Languages : en
Pages : 482
Book Description
As a result of their unique physical properties, biological membrane mimetics, such as liposomes, are used in a broad range of scientific and technological applications. Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evolved from basic studies of the physicochemical properties of amphiphiles to their application in industry and medicine. Written by leading researchers in their fields, this book describes basic and applied research, and serves as a useful reference for both the novice and the expert. Part one covers a range of basic research topics, from theory and computational simulations to some of the most up-to-date experimental research. Topics discussed include soft matter physics of membranes, nonlamellar phases, extraction of molecules by amphiphiles, lipid models for membrane rafts, membrane dynamics, nanodiscs, microemulsions, active membranes, as well as interactions of bilayers with drugs or DNA to treat disease or for gene transfer, respectively. Part two of the book focuses on technological applications of amphiphiles, such as liposome-based nanoparticles for drug delivery, formulation of liposomes for prolonged in vivo circulation and functionalization for medical purposes, novel drug delivery systems for increased drug loading, and the use of tethered membranes for bio-sensing applications. Chapters also describe the use of liposomes in textile dyeing and how lipidic nanoparticles are used by the food industry.

Liposomes

Liposomes PDF Author: Arabinda Chaudhuri
Publisher:
ISBN: 9781788015516
Category :
Languages : en
Pages : 300
Book Description
Liposomal drug and gene delivery systems have found success in clinical applications due to their biodegradable, biocompatible, non-toxic, and non-immunogenic nature. To underscore their importance in healthcare, in the fight against SARS-CoV-2 virus, lipid-based nanoparticular formulations of mRNA and DNA based vaccines have been developed via academic and industry collaboration. Aimed at newcomers and established researchers alike, this book provides a comprehensive coverage of the field. Each chapter emphasizes design principles and concludes with highlighting unmet translational challenges. Topics covered include up-scaling liposome preparation, FDA approved liposomal drug delivery systems (LDDS) for cancer and non-cancerous diseases; liposomes in non-viral gene therapy; receptor selective LDDS for targeted cancer therapy; liposomal delivery of DNA and mRNA vaccines and liposomes for combination therapy. Whilst there are many review articles, this book brings together information and explains the complex science in an accessible manner.Written for an interdisciplinary audience, this book is an up-to-date resource for this important and vibrant research field.

Advances in Nanotechnology-Based Drug Delivery Systems

Advances in Nanotechnology-Based Drug Delivery Systems PDF Author: Anupam Das Talukdar
Publisher: Elsevier
ISBN: 0323904149
Category : Technology & Engineering
Languages : en
Pages : 670
Book Description
Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine. This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines. Provides a clear introduction to nanotechnology in drug delivery, covering key principles, synthesis, characterization and unique properties of nanoscale materials for drug delivery systems“/li> Discusses preclinical, clinical and patented nano-drug delivery systems, enabling the reader to grasp the current state-of-the-art and market Covers a broad range of targets for nanoscale drug delivery systems, such as in neurological disorders, oral disease, renal disease, cancer, skin protection, and much more