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Non-Myeloablative Allogeneic Transplantation

Non-Myeloablative Allogeneic Transplantation PDF Author: Asad Bashey
Publisher: Springer Science & Business Media
ISBN: 146150919X
Category : Medical
Languages : en
Pages : 216
Book Description
Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Non-Myeloablative Allogeneic Transplantation

Non-Myeloablative Allogeneic Transplantation PDF Author: Asad Bashey
Publisher: Springer Science & Business Media
ISBN: 146150919X
Category : Medical
Languages : en
Pages : 216
Book Description
Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Allogeneic Stem Cell Transplantation

Allogeneic Stem Cell Transplantation PDF Author: Hillard M. Lazarus
Publisher: Springer Science & Business Media
ISBN: 1597454788
Category : Medical
Languages : en
Pages : 881
Book Description
Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Allogeneic Stem Cell Transplantation

Allogeneic Stem Cell Transplantation PDF Author: Mary J. Laughlin
Publisher: Springer Science & Business Media
ISBN: 159259333X
Category : Medical
Languages : en
Pages : 454
Book Description
Internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-versus-host disease They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of nonmyeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.

Stem Cell and Gene-Based Therapy

Stem Cell and Gene-Based Therapy PDF Author: Alexander Battler
Publisher: Springer Science & Business Media
ISBN: 9781846286766
Category : Medical
Languages : en
Pages : 460
Book Description
Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Thomas' Hematopoietic Cell Transplantation

Thomas' Hematopoietic Cell Transplantation PDF Author: Stephen J. Forman
Publisher: John Wiley & Sons
ISBN: 144435745X
Category : Medical
Languages : en
Pages : 3655
Book Description
This outstanding reference source on bone marrow transplantation has become recognised as the bible in the field. This fourth edition has been fully revised to reflect latest developments, and now features over 500 illustrations, including a colour plate section. The need for this new edition cannot be overstated - more than 13,000 new cases per year of haematopoietic stem cell transplantation have been reported to the International Bone Marrow Transplant Registry The original editor, Donnall Thomas, was a pioneer in stem cell research and won the 1990 Nobel Prize for his discoveries concerning organ and cell transplantation in the treatment of human diseases. The book also now includes a fully searchable CD with PDFs of the entire content.

DeVita, Hellman, and Rosenberg's Cancer

DeVita, Hellman, and Rosenberg's Cancer PDF Author: Vincent T. DeVita
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781772075
Category : Medical
Languages : en
Pages : 1748
Book Description
Presenting comprehensive, cutting-edge information on the science of oncology and the multimodality treatment of every cancer type, this eighth edition--now in full color--contains more than 40 brand-new chapters, and more than 70 chapters have been rewritten by new contributing authors.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation PDF Author: Robert J. Soiffer
Publisher: Springer Science & Business Media
ISBN: 9781597454384
Category : Medical
Languages : en
Pages : 736
Book Description
Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease. Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair. The updated chapters introduce the biologic underpinnings of hematopoietic cell transplantation, basic stem cell biology, immunobiology, and histocompatibility, with emphasis on indications and results of transplantation for specific diseases. Written by experts in the field, Stem Cell Transplantation for Hematologic Disorders, Second Edition provides seasoned professionals with a complete understanding of the current state of transplantation biology as well as a clear vision into the future.

Leukemia and Related Disorders

Leukemia and Related Disorders PDF Author: Elihu H. Estey
Publisher: Springer Science & Business Media
ISBN: 1607615657
Category : Medical
Languages : en
Pages : 382
Book Description
From the world renowned Fred Hutchinson Cancer Research Center, this book is written for all physicians who treat patients with acute or chronic leukemias or myelodysplasia. It is designed to answer questions about treatment approaches that commonly arise in day-to-day practice. In keeping with the Center’s groundbreaking research in bone marrow transplantation, the book provides exceptional coverage of the role of allogeneic transplant in treatment. It also addresses the important issues of supportive care and long-term complications of successful treatment. •Edited and written by experts at the Fred Hutchinson Cancer Research Center •Clinically focused and comprehensive coverage of treatment approaches •Allogeneic transplant addressed in detail •Separate chapters on supportive care and long-term complications

Plasma Cell Dyscrasias

Plasma Cell Dyscrasias PDF Author: Aldo M. Roccaro
Publisher: Springer
ISBN: 3319403206
Category : Medical
Languages : en
Pages : 361
Book Description
This book provides a concise overview of the state of the art in the biology and treatment of plasma cell malignancies, a heterogeneous group of diseases primarily characterized by the presence of clonal plasma cells within the bone marrow or extramedullary sites. The plasma cell dyscrasias investigated include monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma, plasmacytoma, immunoglobulin deposition diseases (primary amyloidosis and systemic light and heavy chain deposition diseases), and Waldenström’s macroglobulinemia. In the case of multiple myeloma, the coverage ranges from genomic aberrations and microRNAs to treatment for different patient groups, upcoming novel therapies, immunotherapy, and transplantation. The book reflects the significant research advances achieved in this field during the past few years, which have enhanced our understanding of the molecular mechanisms responsible for the pathogenesis of plasma cell dyscrasias.

Neoplastic Diseases of the Blood

Neoplastic Diseases of the Blood PDF Author: Peter H. Wiernik
Publisher: Springer Science & Business Media
ISBN: 1461437644
Category : Medical
Languages : en
Pages : 1431
Book Description
Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia— Chronic Leukemias and Related Disorders , Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.