Therapeutic Strategies in Dementia

Therapeutic Strategies in Dementia PDF Author: Craig W. Ritchie
Publisher: Clinical Pub Serv
ISBN:
Category : Medical
Languages : en
Pages : 384
Book Description
Widely acknowledged as one of the most challenging aspects of dealing with an aging population, the increasing prevalence of cognitive decline in the elderly presents the clinician with a variety of complex therapeutic problems. Alzheimer's disease and other dementias vary in their onset and progression, as do patients in their responsiveness to treatment. In this book, leading experts review the current and evolving therapeutic options, including anti-amyloid therapies, neuroprotective strategies, and symptomatic treatments (both pharmacological and non-pharmacological). Also included are updates on several recent and on-going clinical trials, the development of new biomarkers to aid recognition of disease and earlier intervention, and a discussion of the pharmacoeconomics of treating dementia.

Therapeutic Strategies in Dementia

Therapeutic Strategies in Dementia PDF Author: ProQuest
Publisher:
ISBN:
Category : Electronic books
Languages : en
Pages :
Book Description


Current Thoughts on Dementia

Current Thoughts on Dementia PDF Author: Ghulam Md Ashraf
Publisher: Springer Nature
ISBN: 9811676062
Category : Medical
Languages : en
Pages : 624
Book Description
This informative book discusses the latest research on the risk factors and therapeutics in dementia. WHO calls dementia a public health priority. Dementia manifests as a group of symptoms associated with decline in memory or other thinking skills and is severe enough to reduce a person's ability to perform everyday activities. It occurs frequently among elderly people, but it is not necessarily part of the normal aging process. The book has been divided into two broad sections. The first section reviews the risk factors involved in developing dementia, including various medical conditions, lifestyle choices, as well as genetics. The latter section describes various therapeutic interventions in dementia. Although there is no known cure for dementia, this book underlines the current treatment strategies that could momentarily reduce the symptoms and improve the quality of life of the patients. This book highlights the global effort to find better ways to halt the progression of dementia and develop novel therapeutic strategies. The book would be an interesting read for advanced graduate students and researchers working in the field of neuroscience, genetics, and medicine. It will generate good interest to neurologists, psychiatrists, geriatricians, cardiologists, internal medicine practitioners, epidemiologist, and public health workers.

Novel Therapeutic Strategies for Dementia Diseases

Novel Therapeutic Strategies for Dementia Diseases PDF Author: Agneta Nordberg
Publisher:
ISBN: 9788716148674
Category : Alzheimer's disease
Languages : en
Pages : 39
Book Description


Alzheimer Disease

Alzheimer Disease PDF Author: Ezio Giacobini
Publisher: Springer Science & Business Media
ISBN: 1461581494
Category : Medical
Languages : en
Pages : 510
Book Description
Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.

Alzheimer's Disease

Alzheimer's Disease PDF Author: Khalid Iqbal
Publisher: John Wiley & Sons Incorporated
ISBN:
Category : Medical
Languages : en
Pages : 708
Book Description
Alzheimer’s Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies Edited by Khalid Iqbal New York State Institute for Basic Research, New York, USA Donald R.C. McLachlan Centre for Research on Neurodegenerative Diseases, University of Toronto, Canada Bengt Winblad Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden and Henry M. Wisniewski New York State Institute for Basic Research, New York, USA As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Although recognized as one of the most devastating diseases of the human brain, the etiology and pathogenesis of Alzheimer’s disease are still poorly understood. Continued research is required both into the basic mechanisms of the condition and into developing diagnostic and therapeutic strategies in the clinic. Presented here is a wide-ranging, authoritative and comprehensive coverage of the most recent and significant advances in basic research and clinical investigations of Alzheimer’s disease. Areas represented include neuroimaging, brain energy metabolism, structural and molecular neuropathology, mechanisms of neuronal degeneration, role of brain amyloidosis, risk factors and epidemiology, environmental factors, genetic mechanisms, biomarkers, animal models and the clinical pharmacology of current and future therapeutic strategies. Contributions are drawn from the major research groups around the world, providing an invaluable information and reference source to both basic researchers and clinicians providing primary care for the unfortunate victims of Alzheimer’s disease. Titles of related interest from Wiley: Dahlem LS43: Etiology of Dementia of Alzheimer’s Type 0 471 92075 4 1988 Giaquinto: Aging and the Nervous System 0 471 91835 0 1988 Iqbal et al.: Alzheimer’s Disease and Related Disorders 0 471 56228 9 1989 Hindmarch, Hippius and Wilcock: Dementia: Molecules, Methods and Measures due Summer 1991

Hormones, Cognition and Dementia

Hormones, Cognition and Dementia PDF Author: Eef Hogervorst
Publisher: Cambridge University Press
ISBN: 113948365X
Category : Medical
Languages : en
Pages :
Book Description
A decade ago, oestrogen-containing hormone therapy was viewed as a promising strategy for the prevention and treatment of dementia and age-related cognitive decline. However, treatment trials in women with Alzheimer's disease showed that oestrogens did not reverse cognitive impairment, and clinical trials in healthy older women indicated that oestrogens did not prevent cognitive decline. The Women's Health Initiative Memory Study trial even suggested an increased risk of dementia with treatment late in life. What happened? How are we to understand these findings? What are the implications for middle-aged and older women? What about testosterone, and what about men? And where do we go from here? This book brings together world-renowned experts in basic and clinical research on sex steroids, aging, and cognition to integrate existing findings with emerging new data, and offer challenging hypotheses on these key issues.

Functional Foods and Therapeutic Strategies for Neurodegenerative Disorders

Functional Foods and Therapeutic Strategies for Neurodegenerative Disorders PDF Author: Preetham Elumalai
Publisher: Springer Nature
ISBN: 9811667039
Category : Biology
Languages : en
Pages : 227
Book Description
This book provides a comprehensive summary of the latest knowledge regarding functional foods and new therapeutic strategies for neurodegenerative disorders through explaining specific mechanisms for natural remedies and functional foods as well as alternative treatment and supplementary approaches for neurodegenerative diseases. Many relevant topics are covered, including role of prebiotics, recent applications for dietary polyphenols, marine bioactive compounds for neuro disorders, and age-related disorders. The roles of various remedies and functional foods are explained for various types of diseases, and the book also integrates the role of functional foods and remedies to work with the current therapeutics that are taking place. In parallel, the information presented through this book will also stimulate current status of leading contemporary methods for prohylactic and diagnostic practices, comprising nanoparticles, biomarkers, in silico techniques, and CRISPR-mediated genome editing-based therapy. The book will be essential reading for students and researchers with an interest in natural medicine, drug development, and food therapeutic strategies. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.

Alzheimer's Disease: Clinical Diagnostic and Therapeutic Strategies

Alzheimer's Disease: Clinical Diagnostic and Therapeutic Strategies PDF Author: Juan Daniels
Publisher:
ISBN: 9781632427847
Category :
Languages : en
Pages : 184
Book Description
Alzheimer's disease refers to a chronic neurodegenerative illness which generally starts slowly and worsens over time, and may cause dementia. Dementia includes the brain disorders which cause a gradual but long-term decrease in one's ability to think and remember. Some of the common symptoms of Alzheimer's disease include short-term memory loss, mood swings, disorientation, problems with language and behavioral issues. The causes of Alzheimer's disease are not defined. However, a genetic involvement has been found in most of the cases. Treatment methods include validation therapy, reminiscence therapy, psychotherapy and simulated presence therapy. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of Alzheimer's disease. The topics included herein on Alzheimer's disease are of utmost significance and bound to provide incredible insights to readers. This book includes contributions of doctors and experts which will provide innovative insights into the diagnosis and therapeutic management of this disease.

Alzheimer’s Disease - From Basic Research to Clinical Applications

Alzheimer’s Disease - From Basic Research to Clinical Applications PDF Author: Hermann J. Gertz
Publisher: Springer Science & Business Media
ISBN: 3709175089
Category : Medical
Languages : en
Pages : 320
Book Description
As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Alzheimer’s disease as the most common cause of dementia in the elderly remains a sentinal problem and its underlying pathology is still poorly understood. Available therapeutic strategies require considerable refinement and the development of new therapeutic strategies need input from basic research. Thus continued efforts are necessary both to understand basic mechanisms of the condition and to achieve more powerfull therapies. This volume brings together the reports of basic scientists and clinical investigators. The chapters provide a spectrum of information valuable for clinicians and scientists. This issue bridges the gap between laboratory work in basic science and the development of urgently needed therapeutic strategies. Areas presented are the molecular and cellular biology of the disease, pathogenetic mechanisms and potential therapeutic targets, genetics, risk factors, strategies of prevention and treatment as well as practical aspects of medical and social care for patients with Alzheimer’s disease.